The law, called the 21st Century Cures Act, also includes prize money to encourage Alzheimers experiments. But billions of dollars have so far made little progress in decoding the memory-robbing disease, which affects 5 million Americans. Alzheimers is currently the nations sixth-leading cause of death. Decades of research have not produced a single drug that alters the diseases course. December began with Liked this another major setback: Eli Lilly shared disappointing results of a late-stage clinical trial of its experimental drug solanezumab, which failed to significantly slow Alzheimers progression. But scientists arent giving up on the main hypothesis behind Eli Lillys trial: that Alzheimers can be defeated by using drugs to attack amyloid plaques that build up in the brain of Alzheimers patients. Some scientists believe these cause the disease. Many observers still hold out hope for another promising anti-amyloid drug, Biogens aducanumab, which in an early trial improved cognitive decline in a small number of patients. Other potentially groundbreaking research aims to intervene before patients even feel any symptoms. Using PET scans, scientists can now identify amyloid plaques building up in a patients brain years before they develop Alzheimers.
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